Alclometasone dipropionate

CAS No. 66734-13-2

Alclometasone dipropionate( —— )

Catalog No. M33722 CAS No. 66734-13-2

Alclometasone dipropionate (Sch 22219) is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Alclometasone dipropionate
  • Note
    Research use only, not for human use.
  • Brief Description
    Alclometasone dipropionate (Sch 22219) is a synthetic glucocorticoid, a steroidal compound with antiproliferative, anti-inflammatory, anti-allergic, antipruritic, and vasoconstrictive properties, which is used in the study of skin inflammation.
  • Description
    Alclometasone dipropionate (Sch 22219) is a steroid compound. Alclometasone dipropionate can be used for the research of dermatitis and skin itch.
  • In Vitro
    Alclometasone dipropionate (0.01-100 ng/mL; 24 h) suppresses cytokine production of CD3/CD2 stimulation with IC50s of 5.54, 1.76, 2.09, 0.89, 3.26 and 0.76 ng/mL for IL-2, IL-3, IL-4, IL-5, IFN-γ and GM-CSF, respectively in human PBMC.
  • In Vivo
    Alclometasone dipropionate (0.1% (20 μL); both sides of the ears; once) shows effects on tuberculin- and egg albumin-induced allergic reaction.Animal Model:Lewis rats with tuberculin-induced delayed allergic reactionDosage:0.1% (20 μL)Administration:Both sides of the ears; 0.1% (20 μL) 3 h before and 2 h after tuberculin challenge Result:Partially inhibited the increase in amount of dye leaked.Animal Model:Brown-Norway rats with egg albumin-induced passive cutaneous anaphylaxis reaction Dosage:0.1% (20 μL) Administration:Both sides of the ears; 0.1% (20 μL) 6 h before egg albumin challenge Result:Significantly suppressed the increase in amount of dye leaked in this passive cutaneous anaphylaxis reaction.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66734-13-2
  • Formula Weight
    521.04
  • Molecular Formula
    C28H37ClO7
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C(COC(CC)=O)(=O)[C@]1(OC(CC)=O)[C@]2(C)[C@@](C[C@H]1C)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(C[C@H]3Cl)=CC(=O)C=C4)[H])[H])[H]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sakuma S, et al. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26.?
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